Engineering Human Paraoxonase‐1 Double Mutants to Hydrolyze Organophosphorus Compounds
نویسندگان
چکیده
منابع مشابه
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Variants of human paraoxonase 1 (PON1) are being developed as catalytic bioscavengers for the organophosphorus chemical warfare agents (OP). It is preferable that the new PON1 variants have broad spectrum hydrolase activities to hydrolyze both G- and V-class OPs. H115W PON1 has shown improvements over wild type PON1 in its capacity to hydrolyze some OP compounds. We improved upon these activiti...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.835.11